V.H.POTTY
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Food-drug interaction is a fascinating field of study and the quantum and quality of information available in this area are limited though there has been an explosive growth of drug industry during the last two decades. While new drugs have to undergo extensive human trials before approval for marketing, many drug like substances reach the market in the form of GRAS supplements with very little oversight regarding their use and consequences on the consumer. How these supplements interact with other food constituents/ingredients is a Grey area calling for studies to ascertain their effects. Coenzyme Q10 (CoQ 10) supplements which are now being marketed are not easily absorbed in the intestine and grapefruit which has a cocktail of biochemical substances is found to have beneficial effects in increasing absorption of CoQ.
"CoQ10 has properties similar to vitamins, but since it is naturally synthesized in the body it is not classed as such. Our ability to synthesise the compound peaks at the age of 20 and amounts in our body decrease rapidly after we pass the age of 40. With chemical structure 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone, it is also known as ubiquinone because of its 'ubiquitous' distribution throughout the human body. The coenzyme is concentrated in the mitochondria - the 'power plants' of the cell - and plays a vital role in the production of chemical energy by participating in the production of adenosince triphosphate (ATP), the body's co-called 'energy currency'. There is an ever-growing body of scientific data that shows substantial health benefits of CoQ10 supplementation for people suffering from angina, heart attack and hypertension. The nutrient is also recommended to people on statins to off-set the CoQ-depleting effects of the medication. Other studies have reported that CoQ10 may play a role in the prevention or benefit people already suffering from neurodegenerative diseases".
While many of the claims may or may not stand strict scientific scrutiny, the scientific findings on CoQ absorption cannot be brushed away and grapefruit happens to be one of the well known "health promoting" fruits that has many other properties beyond facilitating CoQ absorption. CoQ-grapefruit complimentary relationship can be an interesting area for further studies, especially to identify the chemical constituent responsible for this phenomenon and the mechanism involved. Grapefruit may also have positive role in facilitating utilization of other hard to absorb nutrients also which needs to be looked into.
V.H.POTTY
The critical role played by long chain Omega-3 fatty acids in maintaining good health, especially brain development, is well established. During pregnancy the intake of this nutrient by the mother and after the birth, intake by the child till the age of 3 determines the pace of brain development. Solid foundation for a healthy and productive life is laid during this time. Subsequent intake has only marginal effect but still necessary to prevent degeneration of neural cells. Major source of Omega-3 fatty acids has been several species of fish but those not habituated to eat fish will have to depend on a variety of foods containing smaller levels of these nutrients or short chain Omega-3 acids like ALA. Lately algae is becoming a good source of long chain Omega 3 acids and commercial technology is now available for large scale production for food fortification.
"The science relating to the health benefits of omega-3 gets stronger and stronger," Ruess stated. "Suppliers have overcome a lot of the technical hurdles for handling omega-3 oils and have progressed in producing various forms, which can be used successfully in a wide range of end-products in foods, beverages, supplements and infant formulas." Analysts estimated the global consumption of marine and algal omega-3 ingredients for 2008 at 71,452 tonnes. North America came first at 26,948 tonnes, Asia-Pacific came second at 21,145 tonnes, followed by the European Union (EU) at 13,596 tonnes and other countries at 5,762 tonnes, AP-Food Technology reports."The [consumption] growth rate has averaged 30-40 per cent annually during the last few years. We still expect significant growth in the next several years," said Frost & Sullivan analyst Chris Shanahan. There is strong and growing scientific evidence on the health benefits of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic)-based omega-3, he said".
Indian food industry will be keenly looking forward to pure, odorless and concentrated Omega-3 fatty acid preparations for enriching a variety of processed products without tainting them. Such products, if and when available, can be a boon to the Indian consumer, most of them depending on diets containing low levels of Omega-3 acids. Alga, being not considered as non-vegetarian, can be acceptable as a source which will enable food industry to include"green dot" on the label signifying its vegetarian pedigree.