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Showing posts with label white fat cells. Show all posts
Showing posts with label white fat cells. Show all posts

Saturday, December 20, 2014

Crazy scientific research! Pray for the "pill", the silver bullet that can trim body weight!

Have you given up on your determination to shed excess body wight because nothing seems to work, whether dieting, exercising, or regularly visiting well being centers? Well there is some crazy researchers in a US university trying to help people like you, trying to develop a "pill" which probably can be included in the medicine chest for regular use along with umpteen number of other pills required these days to ward of bad effects of life style diseases like diabetes, blood pressure, heart disease etc. Though such a scenario is far fetched just now, the ever optimistic scientists are upbeat about the chances of such a pill emerging in not too distant a future. Keep your fingers crossed. The basis of such an optimism is that they were able to identify, after screening thousands of chemicals two specific ones capable of shifting the fat making process in the body through white fat cells to brown fat cells, the latter considered a friendly source of harmless fats that burn easily without getting deposited around the abdomen. Though it may be some what premature to hail these findings, the pioneering scientists deserve a pat on their back. Read further below:  

"Researchers at Harvard University say they have identified two chemical compounds that could replace "bad" fat cells in the human body with healthy fat-burning cells, in what may be the first step toward the development of an effective medical treatment – which could even take the form of a pill – to help control weight gain. Not all fat is created equal. While white fat cells store energy as lipids and contribute to obesity, heart disease and type 2 diabetes, the less common brown fat cells pack energy in iron-rich mitochondria, have been shown to lower triglyceride levels and insulin resistance in mice, and appear to be correlated with lower body weight in humans. Brown fat makes up about five percent of the body mass of healthy newborns, helping them keep warm, and is still present in lower quantities in our neck and shoulders as adults, where it helps burn the white fat cells. Associate professor Chad Cowan and colleagues at Harvard say they have developed a way to identify the chemical compounds that induce fat stem cells to produce "good" brown-like fat cells instead of the "bad" white ones. The scientists say they have already used their system to pinpoint two such compounds that can accomplish this in humans. Other drugs (viagra included) have been known to be able to turn white fat cells into brown, but their effect is only temporary. This new method, however, is reportedly showing a stable conversion of fat cells over time, which has an exciting potential for long-term health improvement. But turning these two chemicals into a practical treatment is not going to be a straightforward process. Aside from the lengthy medical trials still to come, the two compounds identified so far both target the same molecule  –  a molecule that contributes to the inflammatory response. The concern here is that tinkering with it by using the compounds over the long term and without modifications could end up compromising the immune system. Cowan's team achieved this result by screening a catalog of only about one thousand compounds. But now, as the first two are being tested on mice to investigate the long-term effects on metabolism and immune system, the researchers are approaching pharmaceutical companies to gain access to a much larger database of over a million compounds, with the hope of finding a candidate that doesn't have the potential adverse effects of the first two."

One interesting question many binge eaters may have is whether such a pill as and when developed and promoted commercially will allow eating to full "heart's" content without facing the adverse consequences that is the rule of the day!. It is very common to day for people to pop in a Unienzyme dragee or antacids like Digene or Gelusil after a heavy meal and will this new pill help the people to eat much more than what they really need or eat foods which are known to cause over weight? No way, because any pill one takes based on synthetic chemicals is likely to have side effects and consumption of such pills must be limited to the bare minimum, that too for therapeutic purpose only.

V.H.POTTY
http://vhpotty.blogspot.com/
http://foodtechupdates.blogspot.com

Sunday, November 16, 2014

Brown fat Vs White fat - A new Insight into obesity development .

Stem cells are the so called mother cells from which differentiated functionally specific cells are generated. These cells are present in high concentrations in children during their early growth phase but gradually declines as aging sets in. The recent discovery that brown fats which are metabolically more active do not cause obesity may herald a new era for treatment of this epidemic which is assuming alarming proportions, especially among population in wealthy countries. It is a fact that the proportion of brown fat to white fat in children is heavily loaded in favor of the former while in adults it is the other way. Specific fat cells are involved in fat synthesis and if adequate amount of brown fat synthesizing cells are available in the body, white fat accumulation can be slowed down dramatically. These findings open up a new vista for "managing" obesity, diabetes and CVD. Here is a take on this new exciting development.

Until now, it was thought that brown fat stem cells did not exist in adults. Children have large amounts of brown fat that is highly metabolically active, which allows them to eat large amounts of food and not gain weight. "The study was led by Amit N Patel, director of Clinical Regenerative Medicine and Tissue Engineering, and associate professor in the Division of Cardiothoracic Surgery at the University of Utah School of Medicine. Adults generally have an abundance of white fat in their bodies, which leads to weight gain and cardiovascular disease but this is not seen in brown fat, Patel said. As people age the amount of white fat increases and brown fat decreases which contributes to diabetes and high cholesterol. "If you have more brown fat, you weigh less, you're metabolically efficient, and you have fewer instances of diabetes and high cholesterol," Patel said. "The unique identification of human brown fat stem cells in the chest of patients aged from 28 to 84 years is profound. We were able to isolate the human stem cells, culture and grow them, and implant them into a pre-human model which has demonstrated positive effects on glucose levels," said Patel. The new discovery of finding brown fat stem cells may help in identifying potential drugs that may increase the body's own ability to make brown fat or find novel ways to directly implant the brown fat stem cells into patients. Though the above findings are in early stages of elaboration, there is definite indication that it should be possible to manipulate the brown fat to white fat ratio through a genetic approach involving transplantation of brown fat cells or evolving a medicinal approach to increase the ability of the body to make more brown fat." 

Though the research is at an early stage these findings add considerably to the current knowledge about the tendency of some people to put on weight from eating. The possibility of implanting stem cells that can differentiate into brown fat synthesizing cells in obese people opens up exciting possibilities for treatment of diseases like diabetes and CVD. How easy this could be remains to be seen. Also possible is development of suitable medicines that can tilt the scale vis-a-vis the ratio of brown fat to white fat in favor of the former. Of course it may take years before a potential workable therapy becomes a main stream tool to tackle obesity based on these new scientific findings. 

V.H.POTTY
http://vhpotty.blogspot.com/
http://foodtechupdates.blogspot.com