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Showing posts with label pill. Show all posts
Showing posts with label pill. Show all posts

Saturday, December 20, 2014

Crazy scientific research! Pray for the "pill", the silver bullet that can trim body weight!

Have you given up on your determination to shed excess body wight because nothing seems to work, whether dieting, exercising, or regularly visiting well being centers? Well there is some crazy researchers in a US university trying to help people like you, trying to develop a "pill" which probably can be included in the medicine chest for regular use along with umpteen number of other pills required these days to ward of bad effects of life style diseases like diabetes, blood pressure, heart disease etc. Though such a scenario is far fetched just now, the ever optimistic scientists are upbeat about the chances of such a pill emerging in not too distant a future. Keep your fingers crossed. The basis of such an optimism is that they were able to identify, after screening thousands of chemicals two specific ones capable of shifting the fat making process in the body through white fat cells to brown fat cells, the latter considered a friendly source of harmless fats that burn easily without getting deposited around the abdomen. Though it may be some what premature to hail these findings, the pioneering scientists deserve a pat on their back. Read further below:  

"Researchers at Harvard University say they have identified two chemical compounds that could replace "bad" fat cells in the human body with healthy fat-burning cells, in what may be the first step toward the development of an effective medical treatment – which could even take the form of a pill – to help control weight gain. Not all fat is created equal. While white fat cells store energy as lipids and contribute to obesity, heart disease and type 2 diabetes, the less common brown fat cells pack energy in iron-rich mitochondria, have been shown to lower triglyceride levels and insulin resistance in mice, and appear to be correlated with lower body weight in humans. Brown fat makes up about five percent of the body mass of healthy newborns, helping them keep warm, and is still present in lower quantities in our neck and shoulders as adults, where it helps burn the white fat cells. Associate professor Chad Cowan and colleagues at Harvard say they have developed a way to identify the chemical compounds that induce fat stem cells to produce "good" brown-like fat cells instead of the "bad" white ones. The scientists say they have already used their system to pinpoint two such compounds that can accomplish this in humans. Other drugs (viagra included) have been known to be able to turn white fat cells into brown, but their effect is only temporary. This new method, however, is reportedly showing a stable conversion of fat cells over time, which has an exciting potential for long-term health improvement. But turning these two chemicals into a practical treatment is not going to be a straightforward process. Aside from the lengthy medical trials still to come, the two compounds identified so far both target the same molecule  –  a molecule that contributes to the inflammatory response. The concern here is that tinkering with it by using the compounds over the long term and without modifications could end up compromising the immune system. Cowan's team achieved this result by screening a catalog of only about one thousand compounds. But now, as the first two are being tested on mice to investigate the long-term effects on metabolism and immune system, the researchers are approaching pharmaceutical companies to gain access to a much larger database of over a million compounds, with the hope of finding a candidate that doesn't have the potential adverse effects of the first two."

One interesting question many binge eaters may have is whether such a pill as and when developed and promoted commercially will allow eating to full "heart's" content without facing the adverse consequences that is the rule of the day!. It is very common to day for people to pop in a Unienzyme dragee or antacids like Digene or Gelusil after a heavy meal and will this new pill help the people to eat much more than what they really need or eat foods which are known to cause over weight? No way, because any pill one takes based on synthetic chemicals is likely to have side effects and consumption of such pills must be limited to the bare minimum, that too for therapeutic purpose only.

V.H.POTTY
http://vhpotty.blogspot.com/
http://foodtechupdates.blogspot.com

Monday, January 28, 2013

TURMERIC AND INFLAMMATION-NEW FINDINGS

Turmeric has a unique dietary role under the Indian cooking system and there is practically no curry preparation without the presence of this ubiquitous natural condiment. With almost all artificial colors being weeded out of human diet because of the health risks associated with them, Turmeric emerged as a rich source of natural yellow color which is available to day across the world for food industry to use in hundreds of processed food products. More than the color, Turmeric is recognized as a food component with medicinal effects. Besides its antibacterial credentials, the Curcumin that is present in it is considered as an anti inflammatory substance possessing properties to combat a number of human diseases linked to inflammation. Here is the latest findings on Curcumin which seem to be opening new avenues for its effective use in counteracting human diseases among population across the world.. 

"Turmeric has been used widely in Indian cooking for thousands of years, and, in the past two decades, hundreds of studies have determined curcumin helps fight arthritic inflammation, reduces cancer risk and slows the onset of diabetes, said Sukumar, co-director of the breast cancer programme at Johns Hopkins. Curcumin is a potent inhibitor of inflammation, which can exacerbate rheumatoid arthritis and spur cancerous growths, according to Sukumar. The compound inhibits a molecule called NF-kB that plays a key role in initiating inflammation. "What curcumin does is blunt this pathway. That's how it is able to mediate its effect," Sukumar said. Consuming curcumin also has been shown to repair skin damage caused by radiation therapy for cancer, she said. Maitra, Sukumar's colleague, began working a few years ago on a water-soluble form of curcumin that can be taken in pill form. That formulation is still in the experimental stages. The body doesn't readily absorb curcumin so a person has to consume several grams of curcumin a day to get the health benefits, Sukumar said. Pills containing unaltered curcumin are on the market. "The other way, the preferable way, is to add (turmeric) to everything you cook," Sukumar said. To get the full benefits, dissolve turmeric in warm oil and add it to foods, she said".

It is true that Curcumin is not water soluble and most of it, consumed through oral route, does not get absorbed across the intestine having only limited effect on flora associated with the gut. The attempt to increase absorption through its solubilization and creating ready to take preparations like tablets or pills is a welcome effort. Since Indian culinary preparations contain high levels of Turmeric even the limited solubility does help getting adequate quantity into the blood stream to derive the benefits attributed to this food adjunct. It is for those population which do not like the typical flavor of Turmeric in the food, camouflaged preparations are necessary to deliver sufficient dosage to confer the benefit. 
V.H.POTTY
http://vhpotty.blogspot.com/
http://foodtechupdates.blogspot.com